Key result
Calcium channel blocker therapy achieved pulmonary artery pressure and exercise tolerance normalization, and complete reverse right heart remodeling in a young idiopathic PAH patient with positive VRT.
Why the study?
Rare vasoreactive test performance limits effective and cheap CCB therapy in potential long-term vasoresponders with idiopathic PAH, who represent a unique 5-7% subset with highest survival.
Does calcium channel blocker therapy improve pulmonary artery pressure and right heart remodeling in a young patient with idiopathic PAH and positive vasoreactive test?
Case Report (n=1)
Does calcium channel blocker therapy improve pulmonary artery pressure and right heart remodeling in a young patient with idiopathic PAH and positive vasoreactive test?
This case highlights the importance of identifying VRT-positive idiopathic PAH patients, as they can achieve excellent outcomes and reverse right heart remodeling with inexpensive CCB therapy.
Rare vasoreactive test (VRT) performance limits the effective and cheap calcium channel blocker (CCB) therapy in potential long-term vasoresponders patients with idiopathic pulmonary arterial hypertension (PAH). Long-term vasoresponders exhibit the unique (5–7 %) idiopathic PAH population with the highest survival. We presented the clinical case of a young idiopathic PAH with positive VRT and a significant advantage of CCB therapy over PAH-specific therapy. Pulmonary artery pressure and exercise tolerance normalization, complete reverse right heart remodeling were achieved on CCB therapy. Our case emphasized the importance of careful identification of VRT positive idiopathic PAH patients and the meticulous follow-up during CCB treatment.
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Гончарова et al. (2024) conducted a case report in Idiopathic pulmonary arterial hypertension (n=1). Calcium channel blocker (CCB) therapy vs. PAH-specific therapy was evaluated on Pulmonary artery pressure, exercise tolerance, and right heart remodeling. Calcium channel blocker therapy achieved pulmonary artery pressure and exercise tolerance normalization, and complete reverse right heart remodeling in a young idiopathic PAH patient with positive VRT.
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