Key result
Stretch-induced generation of action potentials within the tubular system of skeletal muscle fibers is hypothesized to cause the distinctive electrically silent contractions in rippling muscle disease.
Proposes a novel pathophysiological mechanism for Rippling muscle disease involving stretch-induced, electrically silent action potentials within the tubular system.
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Hypothesis for rippling muscle disease mechanism is untested; leaves open experimental validation before clinical or therapeutic implications.
Graham D. Lamb (2005) conducted a review in Rippling muscle disease (RMD). Stretch-induced generation of action potentials within the tubular system was evaluated. Stretch-induced generation of action potentials within the tubular system of skeletal muscle fibers is hypothesized to cause the distinctive electrically silent contractions in rippling muscle disease.
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