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June 1, 1988CancerOpen Access

Histopathologic grading in spindle cell soft tissue sarcomas

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Why the study?

Does a histopathologic grading system predict metastases and survival in patients with spindle cell soft tissue sarcomas?

Population

125 patients with spindle cell soft tissue sarcomas

Design

Cohort

Authors

JCJean‐Michel CoindreArgonne National LaboratoryNBNguyen Binh BuiCancer Treatment Centers of AmericaFBF. BonichonGuide Dogs

Discussion

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Implication

Supports tumor grade for prognostication in spindle cell sarcomas; leaves open prospective validation before guiding therapy.

Structured PICO

Does a histopathologic grading system predict metastases and survival in patients with spindle cell soft tissue sarcomas?

P
Population
125 patients with spindle cell soft tissue sarcomas (including malignant fibrous histiocytoma, leiomyosarcoma, neurosarcoma, and fibrosarcoma)
I
Intervention
Histopathologic grading system
O
Outcome
Advent of metastases and survivalhard clinical

Histopathologic grading is a significant prognostic factor for predicting metastases and survival in patients with spindle cell soft tissue sarcomas.

Cite This Study

Coindre et al. (1988) studied this question.

synapsesocial.com/papers/6a9785d9d08ffd74dfc618cfhttps://doi.org/10.1002/1097-0142(19880601)61:11<2305::aid-cncr2820611126>3.0.co;2-m
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Malignant fibrous histiocytoma Clinicopathologic and ultrastructural study of 12 cases1978 · 76 citations
  2. 2Conservative surgery and postoperative radiotherapy in 300 adults with soft-tissue sarcomas1981 · 611 citations
  3. 3Reproducibility of a histopathologic grading system for adult soft tissue sarcoma1986 · 455 citations
  4. 4A clinical and pathological staging system for soft tissue sarcomas1977 · 768 citations
  5. 5Soft Tissue Tumors1985 · 2,282 citations