Key result
A case of dermatofibrosarcoma protuberans observed over 15 years showed seven recurrences with increasing cellular density and infiltrating growth, ultimately transforming into a fibrosarcoma.
Case Report (n=1)
Dermatofibrosarcoma protuberans can undergo malignant transformation into fibrosarcoma over a prolonged period with multiple recurrences.
Multiple recurrences in DFSP may signal fibrosarcomatous risk; leaves open whether intensified surveillance alters outcomes.
Report on a case of dermatofibrosarcoma protuberans that was observed clinically and histologically for 15 years. During the course of the disease seven recurrences occurred being characterized by an increasing tendency for malignancy. The tumours showed an increasing number of densely packed cells and revealed a predominantly infiltrating growth, which finally lead to the diagnosis of fibrosarcoma in the latest stage of the disease.
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Hagedorn et al. (2009) conducted a case report in Dermatofibrosarcoma protuberans (n=1). A case of dermatofibrosarcoma protuberans observed over 15 years showed seven recurrences with increasing cellular density and infiltrating growth, ultimately transforming into a fibrosarcoma.
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