Key result
Symptomatic abdominal aortic aneurysm patients had higher periaortic adipose tissue attenuation in aneurysmal (-57.85 HU) and nonaneurysmal segments (-58.16 HU) compared to other groups (P<.0001).
Why the study?
The study was conducted to assess periaortic adipose tissue attenuation at CT angiography across different abdominal aortic aneurysm disease states.
Does periaortic adipose tissue attenuation at CT angiography differ between patients with symptomatic abdominal aortic aneurysms, asymptomatic aneurysms, and controls?
Observational (n=88)
Does periaortic adipose tissue attenuation at CT angiography differ between patients with symptomatic abdominal aortic aneurysms, asymptomatic aneurysms, and controls?
Absolute Event Rate: -57.85% vs -83.27%
p-value: p=<.0001
Symptomatic abdominal aortic aneurysms are associated with increased periaortic adipose tissue CT attenuation, likely reflecting systemic consequences of acute rupture, whereas stable disease shows no such increase.
Periaortic fat attenuation may differ by AAA status; leaves open its role as a biomarker pending validation.
Purpose To assess periaortic adipose tissue attenuation at CT angiography in different abdominal aortic aneurysm disease states. Materials and Methods In a retrospective observational study from January 2018 to December 2022, periaortic adipose tissue attenuation was assessed at CT angiography in patients with asymptomatic or symptomatic (including rupture) abdominal aortic aneurysms and controls without aneurysms. Adipose tissue attenuation was measured using semiautomated software in periaortic aneurysmal and nonaneurysmal segments of the abdominal aorta and in subcutaneous and visceral adipose tissue. Periaortic adipose tissue attenuation values between the three groups were assessed using Student t tests and Wilcoxon rank sum tests followed by a multiregression model. Results Eighty-eight individuals (median age, 70 years [IQR, 65–78]; 78 male and 10 female patients) were included: 70 patients with abdominal aortic aneurysms (40 asymptomatic and 30 symptomatic, including 24 with rupture) and 18 controls. There was no evidence of differences in the periaortic adipose tissue attenuation in the aneurysmal segment in asymptomatic patients versus controls (−81.44 HU ± 7 [SD] vs −83.27 HU ± 9; P = .43) and attenuation in nonaneurysmal segments between asymptomatic patients versus controls (−75.43 HU ± 8 vs −78.81 HU ± 6; P = .08). However, symptomatic patients demonstrated higher periaortic adipose tissue attenuation in both aneurysmal (−57.85 HU ± 7; P < .0001) and nonaneurysmal segments (−58.16 HU ± 8; P < .0001) when compared with the other two groups. Conclusion Periaortic adipose tissue CT attenuation was not increased in stable abdominal aortic aneurysm disease. There was a generalized increase in attenuation in patients with symptomatic disease, likely reflecting the systemic consequences of acute rupture. Keywords: Abdominal Aortic Aneurysm, Periaortic Adipose Tissue Attenuation, CT Angiography ClinicalTrials.gov registration no. NCT02229006 © RSNA, 2024
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Debono et al. (2024) conducted an observational in Abdominal aortic aneurysms (n=88). Symptomatic abdominal aortic aneurysm vs. Asymptomatic patients and controls without aneurysms was evaluated on Periaortic adipose tissue attenuation in aneurysmal segment (p=<.0001). Symptomatic abdominal aortic aneurysm patients had higher periaortic adipose tissue attenuation in aneurysmal (-57.85 HU) and nonaneurysmal segments (-58.16 HU) compared to other groups (P<.0001).
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