Key result
Antidepressant selection is largely governed by the predictable and idiosyncratic adverse effect profiles of various drug classes, including tricyclics, SSRIs, MAOIs, and newer agents.
Why the study?
What are the predictable and idiosyncratic adverse effects of various classes of antidepressants?
What are the predictable and idiosyncratic adverse effects of various classes of antidepressants?
This review summarizes the side-effect profiles of various antidepressant classes, which is the primary driver for medication selection.
Answers are grounded in this paper and cite their sources.
Adverse effect profiles should guide antidepressant selection to minimize harm; leaves open head-to-head trials incorporating comorbidities and patient factors.
The choice of antidepressant is largely governed by its side-effect profile. The predictable and idiosyncratic adverse effects of tricyclic antidepressants, selective serotonin re-uptake inhibitors, monoamine oxidase inhibitors and atypical antidepressants are discussed. Information on the newer agents, such as citalopram, milnacipran, mirtazapine, nefazodone and venlafaxine, is included.
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Mir et al. (1997) studied this question. Antidepressant selection is largely governed by the predictable and idiosyncratic adverse effect profiles of various drug classes, including tricyclics, SSRIs, MAOIs, and newer agents.
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