Key result
The EXPLORE trial is an ongoing randomized study designed to determine whether recanalization of a chronic total occlusion within seven days after primary PCI for STEMI improves left ventricular function.
Why the study?
Does elective percutaneous coronary intervention of a chronic total occlusion in a non-infarct related artery improve left ventricular ejection fraction and end-diastolic volume in STEMI patients after primary PCI?
Population
300 patients after successful primary percutaneous coronary intervention for ST-elevation myocardial…
Comparison
Elective percutaneous coronary intervention of… vs Standard medical treatment.
Design
Other, 1:1 ratio following a computer-generated list, Blinded evaluation of…
Follow-up
4 months for primary endpoint, up to 5 years for clinical…
Authors
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The EXPLORE trial protocol outlines the first randomized study to investigate whether early recanalization of a concurrent CTO after primary PCI for STEMI improves left ventricular function.
RCT (n=300)
Blinded evaluation of endpoints
1:1 computer-generated list
Yes
Does elective percutaneous coronary intervention of a chronic total occlusion in a non-infarct related artery improve left ventricular ejection fraction and end-diastolic volume in STEMI patients after primary PCI?
The EXPLORE trial protocol outlines the first randomized study to investigate whether early recanalization of a concurrent CTO after primary PCI for STEMI improves left ventricular function.
Schaaf et al. (2010) conducted an RCT in ST-elevation myocardial infarction (STEMI) with a chronic total occlusion (CTO) in a non-infarct related artery (n=300). Elective percutaneous coronary intervention (PCI) of the CTO vs. Standard medical treatment was evaluated on Left ventricular ejection fraction (LVEF) and left ventricular end-diastolic volume (LVEDV) assessed by cMRI at 4 months. The EXPLORE trial is an ongoing randomized study designed to determine whether recanalization of a chronic total occlusion within seven days after primary PCI for STEMI improves left ventricular function.
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