Key result
Protein injection designed to produce shock caused pronounced anaphylactic reactions in rabbits and dogs, but no circulatory or respiratory disturbances were observed in 5 monkeys.
Why the study?
Does anaphylactic shock alter pulmonary circulation pressure and respiratory function differently across animal species?
Does anaphylactic shock alter pulmonary circulation pressure and respiratory function differently across animal species?
Anaphylactic shock produces pronounced circulatory and respiratory reactions in rabbits and dogs, but not in monkeys, highlighting significant species differences in pulmonary vascular responses.
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Species differences in anaphylactic responses caution against extrapolating non-primate models; leaves open mechanisms of pulmonary vascular reactivity in primates.
Drinker et al. (1924) studied Anaphylactic shock. Protein injection was evaluated on Circulatory and respiratory phenomena. Protein injection designed to produce shock caused pronounced anaphylactic reactions in rabbits and dogs, but no circulatory or respiratory disturbances were observed in 5 monkeys.
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