Key result
Adrenaline with hydroxyethyl starch restores MAP 15 minutes faster than adrenaline alone in animal anaphylaxis.
Why the study?
There is no solid evidence for the choice of one specific type of fluid over another for volume expansion combined with adrenaline in anaphylactic shock resuscitation.
Does adrenaline combined with volume expansion reduce the time to achieve target mean arterial pressure compared to adrenaline alone in a rat model of anaphylactic shock?
Does adrenaline combined with volume expansion reduce the time to achieve target mean arterial pressure compared to adrenaline alone in a rat model of anaphylactic shock?
Absolute Event Rate: 10% vs 25%
In a rat model of anaphylactic shock, combining adrenaline with volume expansion (especially hydroxyethyl starch) achieved target mean arterial pressure faster than adrenaline alone.
No takes yet. Share an insight, caveat, or question.
Volume expansion may hasten MAP recovery in anaphylactic shock models; hypothesis-generating in this rat study, needs clinical validation.
Tajima et al. (2013) studied Anaphylactic shock (n=25). Adrenaline with hydroxyethyl starch (AD+HES) or isotonic saline (AD+IS) vs. Adrenaline alone was evaluated on Time to reach a target mean arterial pressure value of 75 mmHg (minutes). Adrenaline combined with hydroxyethyl starch achieved target mean arterial pressure faster (median 10 minutes) than adrenaline alone (median 25 minutes) in an animal model of anaphylactic shock.
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