Key result
Lansoprazole 30 mg once daily provided more rapid onset of heartburn relief than omeprazole 20 mg once daily, with 33% vs 25% of patients heartburn-free on day 1 (p<0.05).
Why the study?
Does lansoprazole improve heartburn relief compared to omeprazole in patients with erosive esophagitis?
Population
3510 patients with erosive esophagitis and at least one episode of moderate to very severe daytime and/or…
Comparison
Lansoprazole 30 mg once daily for 8 weeks vs Omeprazole 20 mg once daily for 8 weeks
Design
RCT, randomized, double-blind
Follow-up
8 weeks
Authors
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Supports preferring lansoprazole for faster initial relief in erosive esophagitis; extends RCT evidence on differential PPI onset.
RCT (n=3,510)
Double-blind
randomized
Yes
Does lansoprazole improve heartburn relief compared to omeprazole in patients with erosive esophagitis?
Absolute Event Rate: 33% vs 25%
p-value: p=<0.05
Lansoprazole 30 mg daily provides faster and more effective heartburn relief than omeprazole 20 mg daily in patients with erosive esophagitis.
Joel E. Richter (2001) conducted an RCT in erosive esophagitis (n=3,510). Lansoprazole vs. Omeprazole 20 mg once daily was evaluated on Percentage of heartburn-free days and heartburn-free nights, and average severity of daytime and nighttime heartburn (p=<0.05). Lansoprazole 30 mg once daily provided more rapid onset of heartburn relief than omeprazole 20 mg once daily, with 33% vs 25% of patients heartburn-free on day 1 (p<0.05).
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