Key result
Natriuretic peptides regulate electrogenic transport processes via cGMP-dependent (ANP, BNP, URO) and cGMP-independent (CNP) pathways that depolarize the membrane voltage of human kidney epithelial cells.
Population
Immortalized human kidney epithelial (IHKE-1) cells derived from proximal tubules
Comparison
Natriuretic peptides vs Baseline/control conditions
Design
Preclinical
Authors
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Extends natriuretic peptide signaling to human renal epithelia; leaves open in vivo cardiorenal translation.
Natriuretic peptides regulate electrogenic transport processes in human kidney epithelial cells via both cGMP-dependent and -independent pathways.
Hirsch et al. (1999) studied this question. Natriuretic peptides (ANP, BNP, URO, CNP) was evaluated on Membrane voltage (Vm) depolarization and cGMP levels. Natriuretic peptides regulate electrogenic transport processes via cGMP-dependent (ANP, BNP, URO) and cGMP-independent (CNP) pathways that depolarize the membrane voltage of human kidney epithelial cells.
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