Key result
In A10 vascular smooth muscle cells, vasopressin-dependent desensitization of the natriuretic peptide receptor NPR-B is mediated by elevated intracellular calcium, not protein kinase C.
Population
A10 vascular smooth muscle cells
Design
Preclinical
Authors
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Challenges PKC mediation of NPR-B desensitization; hypothesis-generating for calcium-targeted vascular studies before clinical translation.
The study demonstrates that vasopressin-dependent inhibition of the natriuretic peptide receptor NPR-B in vascular smooth muscle cells is mediated by elevated intracellular calcium rather than protein kinase C.
Abbey et al. (2002) studied Vascular smooth muscle cell signaling. Arginine-vasopressin (AVP), BAPTA-AM, ionomycin was evaluated on Desensitization of NPR-B. In A10 vascular smooth muscle cells, vasopressin-dependent desensitization of the natriuretic peptide receptor NPR-B is mediated by elevated intracellular calcium, not protein kinase C.
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