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July 1, 1997Cardiovascular ResearchOpen Access

Mechanisms of natriuretic-peptide-induced growth inhibition of vascular smooth muscle cells

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Population

Rat vascular smooth muscle cells (VSMC), passages 4-12

Design

Preclinical

Authors

HHHoward G. HutchinsonAstraZeneca (United States)

Discussion

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Implication

NPR-C unlikely to mediate natriuretic peptide antiproliferative effects; leaves open receptor targeting for vascular disease models.

Structured PICO

P
Population
Rat vascular smooth muscle cells (VSMC), passages 4-12
I
Intervention
Atrial natriuretic peptide (ANP), C-type natriuretic peptide (CNP), and NPR-C specific ligands
O
Outcome
Cell growth measured by [3H]thymidine incorporation and MAP kinase activitysurrogate

The antiproliferative actions of natriuretic peptides on vascular smooth muscle cells are mediated by guanyl-cyclase-linked receptors rather than the clearance receptor NPR-C.

Cite This Study

Howard G. Hutchinson (1997) studied this question.

synapsesocial.com/papers/6a7564001646b2abe5036b95https://doi.org/10.1016/s0008-6363(97)00086-2
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Phenotype-related alteration in expression of natriuretic peptide receptors in aortic smooth muscle cells.1992 · 127 citations
  2. 2Differential regulation of natriuretic peptide receptor messenger RNAs during the development of cardiac hypertrophy in the rat.1993 · 81 citations
  3. 3Natriuretic Peptides Inhibit DNA Synthesis in Cardiac Fibroblasts1995 · 273 citations
  4. 4Differential antimitogenic effectiveness of atrial natriuretic peptides in primary versus subcultured rat aortic smooth muscle cells: Relationship to expression of ANF‐C receptors1993 · 34 citations
  5. 5Atrial natriuretic peptide inhibits the production and secretion of endothelin from cultured endothelial cells. Mediation through the C receptor.1992 · 117 citations