Key result
Chronic kidney disease and end-stage renal disease were associated with a statistically significant progressive upregulation in mean concentrations of inflammatory biomarkers compared to controls.
Why the study?
Are inflammatory biomarkers progressively upregulated in patients with chronic kidney disease and end-stage renal disease compared to age-matched controls?
Population
Patients with chronic kidney disease stages 2-4, end-stage renal disease, and age-matched controls
Design
Cross-sectional
Authors
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May inform inflammatory assessment in CKD/ESRD; hypothesis-generating for CV risk, prospective studies needed before practice change.
Observational
Are inflammatory biomarkers progressively upregulated in patients with chronic kidney disease and end-stage renal disease compared to age-matched controls?
Inflammatory biomarkers progressively increase with worsening kidney disease, which may help evaluate the underlying inflammatory state and potential cardiovascular risk.
Sharain et al. (2012) conducted an observational in Chronic Kidney Disease and End-Stage Renal Disease. Chronic kidney disease and end-stage renal disease vs. Age-matched controls was evaluated on Mean concentration of inflammatory biomarkers (C-reactive protein, d-dimer, neuron-specific enolase, neutrophil gelatinase-associated lipocalin, tumor necrosis factor receptor I, and thrombomodulin). Chronic kidney disease and end-stage renal disease were associated with a statistically significant progressive upregulation in mean concentrations of inflammatory biomarkers compared to controls.
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