Key result
Chronic kidney disease was associated with significantly elevated levels of ADMA (0.15 vs 0.08 µmol/l), TNF-α, and CRP compared to healthy controls, which worsened as kidney function deteriorated.
Why the study?
Examining inflammation and endothelial dysfunction is critical to preventing cardiovascular diseases in CKD patients because both processes are involved in cardiovascular pathogenesis.
Cross-Sectional (n=82)
Yes
Biomarkers of inflammation and endothelial dysfunction progressively increase as kidney function deteriorates in CKD patients, potentially aggravating cardiovascular risk.
Answers are grounded in this paper and cite their sources.
May signal rising CV risk in CKD; leaves open whether targeting these biomarkers improves outcomes.
Inflammation and endothelial dysfunction have been known to be involved in the pathogenesis of cardiovascular diseases. As such, examining the levels of inflammation and endothelial dysfunction is very critical to the prevention of cardiovascular diseases among chronic kidney disease (CKD) patients. This study aimed to investigate the progression of inflammation and endothelial dysfunction among CKD patients in Sokoto. A total of 67 CKD patients were divided into 5 groups based on the stages of their kidney disease calculated using the MDRD 4-variable equation for estimated glomerular filtration rate (eGFR). The presence of inflammation was determined by C-Reactive Protein (CRP) and Tumor Necrosis Factor alpha, while endothelial dysfunction was determined by the levels of Asymmetric dimethylarginine (ADMA) using ELISA kits. The mean eGFR of the patients was 49.97 ± 4.69 ml/min/1.73m2. There was significant increase (p<0.05) in CRP, TNF-α and ADMA of the CKD patients across the stages as compared to the non-CKD subjects. It was observed that as the CRP, TNF-α and ADMA increase, the eGFR significantly (p<0.05) decreases. Both CRP and TNF-α indicated a significantly positive correlation (p<0.05) with ADMA. The results indicated progressive increase in inflammation and endothelial dysfunction as CKD deteriorates. In addition, increased levels of inflammation could directly affect endothelial dysfunction, thereby aggravating cardiovascular morbidity and mortality among CKD patients in Sokoto. Otitolaiye, C. A. | Department of Biochemistry, Sokoto State University, Sokoto, Nigeria
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Otitolaiye et al. (2021) conducted a cross-sectional in Chronic Kidney Disease (n=82). Chronic Kidney Disease vs. Healthy controls was evaluated on Plasma Asymmetric Dimethylarginine (ADMA) levels (µmol/l) (p=0.0036). Chronic kidney disease was associated with significantly elevated levels of ADMA (0.15 vs 0.08 µmol/l), TNF-α, and CRP compared to healthy controls, which worsened as kidney function deteriorated.
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