Key result
Presence of a raphe in bicuspid aortic valves was associated with higher aortic regurgitation (79.5% vs 37.8%, P<0.001) but lower aortic stenosis (48.6% vs 78.0%, P<0.001) compared to its absence.
Why the study?
To identify the association between the presence or absence of raphe and aortic valve dysfunction, as well as the presence of aortopathy, in patients with BAV.
Does the presence of a raphe affect the prevalence of aortic valve dysfunction and aortopathy in patients with bicuspid aortic valve disease?
Observational (n=312)
Does the presence of a raphe affect the prevalence of aortic valve dysfunction and aortopathy in patients with bicuspid aortic valve disease?
In patients with bicuspid aortic valve, the presence of a raphe is independently associated with a higher prevalence of aortic regurgitation and a lower prevalence of aortic stenosis.
Raphe assessment may refine BAV phenotyping; leaves open progression risk and aortopathy impact.
(1) Background: To identify the association between the presence or absence of raphe and aortic valve dysfunction as well as the presence of aortopathy in patients with bicuspid aortic valve (BAV); (2) Methods: This retrospective study enrolled 312 participants (mean [SD] age, 52.7 [14.3] years; 227 men [72.8%]) with BAV. The BAVs were divided into those with presence (raphe+) or absence (raphe-) of raphe. Valvular function was classified as normal, aortic regurgitation (AR), or aortic stenosis (AS) using TTE. The pattern of BAV aortopathy was determined by the presence of dilatation at the sinus of Valsalva and the middle ascending aorta using CCT.; (3) Results: BAVs with raphe+ had a higher prevalence of AR (148 [79.5%] vs. 48 [37.8%], P < .001) but a lower prevalence of AS (90 [48.6%] vs. 99 [78.0%], P < .001) compared with those with raphe-. The types of BAV aortopathy were significantly different (P = 0.021) according to those with BAV-raphe+ and BAV-raphe-.; (4) Conclusions: The presence of a raphe was significantly associated with a higher prevalence of AR but a lower prevalence of AS and combined dilatation of the aortic root and middle ascending aorta. The presence of raphe was an independent determinant of AR.
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Zhang et al. (2023) conducted an observational in Bicuspid aortic valve disease (n=312). Presence of raphe vs. Absence of raphe was evaluated on Aortic regurgitation (p=< .001). Presence of a raphe in bicuspid aortic valves was associated with higher aortic regurgitation (79.5% vs 37.8%, P<0.001) but lower aortic stenosis (48.6% vs 78.0%, P<0.001) compared to its absence.
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