Key result
A whey protein and guar gum preload reduced plasma glucose (p=0.02) and glucose absorption (p=0.003) after an oral glucose load, without slowing gastric emptying.
Why the study?
Previous assessments could not discriminate between gastric emptying slowing and small intestinal absorption, and a whey protein/guar gum preload may also be useful for managing postprandial hypotension.
Does a whey protein and guar gum-containing preload improve postprandial glycaemia and blood pressure in healthy older subjects?
Does a whey protein and guar gum-containing preload improve postprandial glycaemia and blood pressure in healthy older subjects?
p-value: p=0.02
A whey protein and guar gum preload lowers postprandial glucose in healthy older adults by delaying small intestinal absorption and stimulating insulin, rather than by slowing gastric emptying.
Should not yet change T2D or hypotension management; leaves open distinct effects on gastric emptying versus absorption.
A whey protein/guar gum preload reduces postprandial glycaemia in type 2 diabetes through slowing gastric emptying. However, gastric emptying has previously been assessed using a stable isotope breath test technique, which cannot discriminate between slowing of gastric emptying and small intestinal absorption. This preload also may be useful in the management of postprandial hypotension. We evaluated the effects of a whey protein/guar preload on gastric emptying, glucose absorption, glycaemic/insulinaemic and blood pressure (BP) responses to an oral glucose load. Eighteen healthy older participants underwent measurements of gastric emptying (scintigraphy), plasma glucose and insulin, glucose absorption, superior mesenteric artery (SMA) flow, BP and heart rate (HR) after ingesting a 50 g glucose drink, with or without the preload. The preload reduced plasma glucose (p = 0.02) and serum 3-O-methylglucose (3-OMG) (p = 0.003), and increased plasma insulin (p = 0.03). There was no difference in gastric emptying or BP between the two days. The reduction in plasma glucose on the preload day was related to the reduction in glucose absorption (r = 0.71, p = 0.002). In conclusion, the glucose-lowering effect of the preload may relate to delayed small intestinal glucose absorption and insulin stimulation, rather than slowing of gastric emptying.
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Pham et al. (2019) studied Healthy (n=18). Whey protein and guar gum preload vs. No preload was evaluated on Plasma glucose (p=0.02). A whey protein and guar gum preload reduced plasma glucose (p=0.02) and glucose absorption (p=0.003) after an oral glucose load, without slowing gastric emptying.
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