Chronic Hypocalcemia in a Patient with Parathyroid Clear-Cell Hyperplasia

This is the authors' abstract. We don't add key points for this paper.

THE etiology of hypocalcemia is usually not difficult to define. In most cases it is due to one of the following: postoperative, idiopathic or pseudohypoparathyroidism; rickets and osteomalacia; chronic renal disease with azotemia; renal tubular acidosis; hypoalbuminemia; or malabsorption syndrome.The present report concerns a patient with long standing hypocalcemia not readily explained by any of the known causes. Parathyroid exploration demonstrated gross enlargement of the glands, which, on histologic study, revealed clear-cell hyperplasia. A partial defect in synthesis of parathyroid hormone resulting in compensatory hyperplasia, an end-organ (bone) refractoriness to the effect of parathyroid hormone and a hypersecretion of . . .