Key result
Acute high-intensity eccentric exercise increased central arterial stiffness and decreased FMD, with changes in β-stiffness index negatively correlated with changes in FMD (r=-0.891, p<0.01).
Why the study?
Does acute high-intensity eccentric exercise reduce vascular endothelial function and increase central arterial stiffness in healthy young men?
Does acute high-intensity eccentric exercise reduce vascular endothelial function and increase central arterial stiffness in healthy young men?
Acute high-intensity eccentric exercise transiently increases central arterial stiffness and decreases endothelial function in healthy young men.
May transiently impair vascular function after eccentric exercise; hypothesis-generating for recovery mechanisms and training effects.
Choi, Y, Akazawa, N, Zempo-Miyaki, A, Ra, S-G, Shiraki, H, Ajisaka, R, and Maeda, S. Acute effect of high-intensity eccentric exercise on vascular endothelial function in young men. J Strength Cond Res 30(8): 2279-2285, 2016-Increased central arterial stiffness is as an independent risk factor for cardiovascular disease. Evidence regarding the effects of high-intensity resistance exercise on vascular endothelial function and central arterial stiffness is conflicting. The purpose of this study was to examine the effects of acute high-intensity eccentric exercise on vascular endothelial function and central arterial stiffness. We evaluated the acute changes in endothelium-dependent flow-mediated dilation (FMD), low-flow-mediated constriction (L-FMC), and arterial stiffness after high-intensity eccentric exercise. Seven healthy, sedentary men (age, 24 ± 1 year) performed maximal eccentric elbow flexor exercise using their nondominant arm. Before and 45 minutes after eccentric exercise, carotid arterial compliance and brachial artery FMD and L-FMC in the nonexercised arm were measured. Carotid arterial compliance was significantly decreased, and β-stiffness index significantly increased after eccentric exercise. Brachial FMD was significantly reduced after eccentric exercise, whereas there was no significant difference in brachial L-FMC before and after eccentric exercise. A positive correlation was detected between change in arterial compliance and change in FMD (r = 0.779; p ≤ 0.05), and a negative correlation was detected between change in β-stiffness index and change in FMD (r = -0.891; p < 0.01) with eccentric exercise. In this study, acute high-intensity eccentric exercise increased central arterial stiffness; this increase was accompanied by a decrease in endothelial function caused by reduced endothelium-dependent vasodilation but not by a change in endothelium-dependent vasoconstriction.
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Choi et al. (2014) studied Healthy, sedentary (n=7). Maximal eccentric elbow flexor exercise vs. Baseline (before exercise) was evaluated on Carotid arterial compliance, brachial artery FMD, and L-FMC. Acute high-intensity eccentric exercise increased central arterial stiffness and decreased FMD, with changes in β-stiffness index negatively correlated with changes in FMD (r=-0.891, p<0.01).
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