Key result
Rats with low baseline heart functional capacity exhibited a prolonged 36% reduction in the average rate of myocardial relaxation and sustained suppression of heart rate variability 35 days after ischemic stroke, whereas those with high capacity recovered.
The risk of cardiovascular complications and recovery prospects after ischemic stroke in an animal model are associated with individual baseline heart functional capacities.
Baseline cardiac capacity may stratify post-stroke autonomic risk in rats; hypothesis-generating and leaves open human translation.
Objective. Ischemic stroke increases the risk of cardiovascular diseases. Our study aimed to identify individual hemodynamic changes and the regulation of heart rate after ischemic stroke in animals with different functionalities heart. Methods. The work was carried out on male Wistar rats, weighing 280–320 g. The following methods were used to study: photoinduced local IS, functional tests, telemetry monitoring ECG, echocardiography, magnetic resonance imaging. Results. In the subacute period of IS, animals with low and high heart functional capacity (HFC) show hemodynamic compromises of various severity. During the recovery period, the suppressed activity of the majority of heart rate variability, which took place in the acute and subacute periods, persisted in the animals with low HFC. In animals with high HFC, nature of the autonomic heart regulation did not differ from the controls. Conclusion. Risk of cardiovascular complications and prospect of recovery after stroke are not only associated with character of cerebral lesions, but also with individual heart functional capacities.
No takes yet. Share an insight, caveat, or question.
Мамалыга et al. (2017) studied Ischemic stroke. Low heart functional capacity vs. High heart functional capacity was evaluated on Hemodynamic and heart rate variability parameters at 35 days post-stroke. Rats with low baseline heart functional capacity exhibited a prolonged 36% reduction in the average rate of myocardial relaxation and sustained suppression of heart rate variability 35 days after ischemic stroke, whereas those with high capacity recovered.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: