Why the study?
Detailed three-dimensional assessment of left ventricular wall motion abnormalities in patients with coronary artery disease using cardiac magnetic resonance was lacking.
Does triple vessel coronary artery disease alter left ventricular radial, rotational, and longitudinal wall motion as assessed by cardiac magnetic resonance tissue phase mapping compared to healthy controls?
Cross-Sectional (n=28)
Does triple vessel coronary artery disease alter left ventricular radial, rotational, and longitudinal wall motion as assessed by cardiac magnetic resonance tissue phase mapping compared to healthy controls?
High-resolution CMR tissue phase mapping reveals that severe coronary artery disease is associated with complex 3D left ventricular wall motion abnormalities, notably marked reductions in peak diastolic longitudinal velocities and strain rates.
Answers are grounded in this paper and cite their sources.
Reduced basal diastolic velocities may indicate subclinical LV impairment in severe CAD; hypothesis-generating for CMR tissue phase mapping in CAD assessment.
Objective: To obtain new details of three-dimensional Left Ventricular (LV) wall motion in patients with Coronary Artery Disease (CAD) using cardiac magnetic resonance navigator gated high temporal resolution tissue phase mapping.Methods: LV motion patterns, myocardial velocities and time-to-peak values for radial, rotational and longitudinal motion were obtained in 19 patients with triple vessel CAD and in a group of 9 age-matched healthy subjects.Radial, circumferential and longitudinal velocity curves were recorded separately for 16 ventricular segments.Ventricular torsion rate and longitudinal strain rate were also derived for each group.Results: Markedly reduced peak diastolic longitudinal velocities (-7.9 ± 0.6 versus -14.1 ± 1.1cm/s) and peak diastolic longitudinal strain rates (1.1 ± 0.2 versus 2.7 ± 0.1s -1 ) were the most prominent findings in CAD.Patients with CAD also demonstrated lower peak radial velocities, the difference increasing towards the LV apex (peak systolic values of 3.1 ± 0.2 versus 3.5 ± 0.2cm/s at the LV base and 2.4 ± 0.2 versus 3.5 ± 0.2cm/s at the LV apex), with sub-endocardial myocardium being affected to a greater extent.Prominent changes in rotational velocities and an altered pattern of ventricular rotation were also noted in CAD patients. Conclusion:The study revealed complex alterations in radial, rotational and longitudinal LV wall motion in patients with CAD.Peak diastolic longitudinal velocity at the LV base and peak diastolic longitudinal strain rate seem particularly useful for detecting early changes in LV dysfunction associated to CAD.Evaluation of the pathophysiological interplays and underlying mechanisms of these changes require further studying and can provide new insights into understanding the pathophysiology of CAD.
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Ion Codreanu (2015) conducted a cross-sectional in Coronary Artery Disease (n=28). Triple vessel coronary artery disease vs. Age-matched healthy controls was evaluated on Peak diastolic longitudinal velocity at the LV base (transmural) (p=<0.01).
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