Key result
This review summarizes current knowledge of influenza A virus selective genome packaging and the possible mechanisms underlying the selection of the eight unique viral RNAs.
Why the study?
The characteristics of RNA-based interactions mediating selective packaging of the eight unique influenza A virus vRNA segments largely remain unknown.
This review provides an overview of the RNA-based intersegment interactions underlying the selective genome packaging of influenza A viruses.
Guides IAV antiviral design targeting packaging signals; confirms selective vRNA interactions while leaving structural details open.
The genome of influenza A virus (IAV) comprises eight segmented, single-stranded, negative-sense RNAs. The genome packaging mechanism of IAV was a long-standing enigma, but it is now widely accepted that IAV packages one copy of each of the eight viral RNA (vRNA) segments in a selective manner. Accumulating evidence over the last decade suggests that the eight unique vRNAs are selected via intersegment interactions mediated by their segment-specific genome packaging signals; however, the characteristics of these RNA-based interactions largely remain unknown. This review summarizes our current knowledge of IAV selective genome packaging and the possible mechanisms underlying the selection of the eight unique vRNAs.
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Takeshi Noda (2020) conducted a review in Influenza A virus. This review summarizes current knowledge of influenza A virus selective genome packaging and the possible mechanisms underlying the selection of the eight unique viral RNAs.
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