Key result
Laparoscopic sleeve gastrectomy in Japanese patients resulted in a 29.9% total weight loss at 2 years, with a 20% TWL identified as a candidate cut-off for diabetes remission.
Why the study?
What are the background characteristics and outcomes of insufficient weight loss after laparoscopic sleeve gastrectomy in Japanese patients?
Observational (n=322)
Yes
What are the background characteristics and outcomes of insufficient weight loss after laparoscopic sleeve gastrectomy in Japanese patients?
A 20% total weight loss at 2 years is a potential cut-off for diabetes remission after laparoscopic sleeve gastrectomy in Japanese patients, with mental disorders linked to intractable obesity.
Supports %TWL <20% as threshold for inadequate diabetes remission after LSG; leaves open mental disorders as driver of insufficient weight loss in Japanese patients.
AIM: Laparoscopic sleeve gastrectomy (LSG) is becoming popular in Japan, but insufficient weight loss is often observed in patients after LSG. We investigated the effect of LSG on obesity-related comorbidities and identified the background characteristics of Japanese patients with insufficient weight loss after LSG. METHODS: In this multi-institutional retrospective study at 10 certified bariatric institutions, 322 Japanese patients who underwent LSG with a follow-up period of more than 2 years were analyzed. Anthropometry, obesity-related comorbidities and psychosocial background data were collected. Weight loss was expressed as 2-year percent total weight loss (%TWL). RESULTS: at 2 years and %TWL was 29.9%. Improvements in the markers and prevalence of obesity-related comorbidities were observed. Remission rates of diabetes, dyslipidemia and hypertension were 75.6%, 59.7% and 41.8%, respectively. %TWL at the respective cut-off level of diabetes remission was 20.8%. Lower remission rates of diabetes in patients with %TWL <20%, and less calorie restriction and higher prevalence of mental disorders (46.9%) in patients with %TWL <15% were observed. Frequencies of %TWL <15% and <20% were 6.5% and 18.5%, respectively. CONCLUSION: %TWL 20% was a candidate cut-off point of insufficient weight loss for diabetes remission after LSG, and mental disorders might be relevant to intractable obesity in Japanese patients.
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Saiki et al. (2019) conducted an observational in Obesity (n=322). Laparoscopic sleeve gastrectomy was evaluated on 2-year percent total weight loss (%TWL). Laparoscopic sleeve gastrectomy in Japanese patients resulted in a 29.9% total weight loss at 2 years, with a 20% TWL identified as a candidate cut-off for diabetes remission.
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