Key result
Left stellate ganglion block significantly reduced contractility in the posterobasal myocardium (-162 vs -80 mm Hg; P<0.01) and increased myocardial asynchrony.
Why the study?
Does left stellate ganglion block impair left ventricular function in an anesthetized canine model?
Does left stellate ganglion block impair left ventricular function in an anesthetized canine model?
Absolute Event Rate: -80% vs -162%
p-value: p=< 0.01
Left stellate ganglion block acutely impairs regional contractility, increases left ventricular asynchrony, and impairs diastolic function in a canine model, suggesting potential adverse hemodynamic effects in patients with compromised hearts.
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May caution use in patients with compromised LV function; leaves open translation to clinical outcomes.
Schlack et al. (1994) studied this question. Left stellate ganglion block (LSGB) vs. Before LSGB (baseline) was evaluated on Contractility in the posterobasal myocardium (Mw) (p=< 0.01). Left stellate ganglion block significantly reduced contractility in the posterobasal myocardium (-162 vs -80 mm Hg; P<0.01) and increased myocardial asynchrony.
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