Key result
Isradipine effectively reduced left ventricular mass index from a baseline of 175.0 g/m2 to 124.8 g/m2 at 90 days in patients with mild-to-moderate hypertension (P<0.001).
Why the study?
Does isradipine reduce left ventricular hypertrophy in patients with mild-to-moderate hypertension?
Does isradipine reduce left ventricular hypertrophy in patients with mild-to-moderate hypertension?
Short-term treatment with isradipine effectively reduces blood pressure and reverses left ventricular hypertrophy in patients with mild-to-moderate hypertension.
Answers are grounded in this paper and cite their sources.
May support LV mass reduction with isradipine; hypothesis-generating and requires RCT confirmation before practice change.
This was a study of the effectiveness of isradipine, a calcium antagonist of the dihydropyridine group, in reversing left ventricular hypertrophy (LVH) in patients with mild-to-moderate hypertension. Mean arterial pressure was effectively reduced at 90 days of treatment (from 129.5 +/- 2.0 to 111.5 +/- 2.8 mm Hg; P less than .001). The electrocardiographic Romhilt-Estes score for LVH showed early reduction at 45 days of treatment (from 7.1 +/- 0.6 to 5.1 +/- 0.4 points; P less than .001), and further diminutions were observed at 90 days of treatment (3.8 +/- 0.4 points; P less than .01). The echocardiographically determined left ventricular mass indices confirmed these findings (from 175.0 +/- 8.9 to 141.7 +/- 5.5 and to 124.8 +/- 4.2 g/m2; P less than .001) for 45 and 90 days, respectively. The results indicate that isradipine is effective in reducing left ventricular mass and that these reductions are observed early in the course of treatment.
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Saragoça et al. (1991) studied Mild-to-moderate hypertension with left ventricular hypertrophy. Isradipine was evaluated on Left ventricular mass index (p=<.001). Isradipine effectively reduced left ventricular mass index from a baseline of 175.0 g/m2 to 124.8 g/m2 at 90 days in patients with mild-to-moderate hypertension (P<0.001).
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