Key result
A 45° rotation of the prosthetic aortic valve from the standard implantation orientation optimized blood flow parameters including flow resistance, shear stress, and velocity in a computational model.
Why the study?
Does the rotational mounting position of an aortic prosthetic valve improve blood flow hemodynamics in a virtual patient model?
Does the rotational mounting position of an aortic prosthetic valve improve blood flow hemodynamics in a virtual patient model?
Computational fluid dynamics modeling suggests that a 45° rotation from the standard implantation orientation of aortic prosthetic valves optimizes blood flow.
Diseases of the cardiovascular system account for nearly 42% of all deaths in the European Union. In Germany, approximately 12,000 patients receive surgical replacement of the aortic valve due to heart valve disease alone each year. A three-dimensional (3D) numerical model based on patient-specific anatomy derived from four-dimensional (4D) magnetic resonance imaging (MRI) data was developed to investigate preoperatively the flow-induced impact of mounting positions of aortic prosthetic valves to select the best orientation for individual patients. Systematic steady-state analysis of blood flow for different rotational mounting positions of the valve is only possible using a virtual patient model. A maximum velocity of 1 m/s was used as an inlet boundary condition, because the opening angle of the valve is at its largest at this velocity. For a comparative serial examination, it is important to define the standardised general requirements to avoid impacts other than the rotated implantation of the prosthetic aortic valve. In this study, a uniform velocity profile at the inlet for the inflow of the aortic valve and the real aortic anatomy were chosen for all simulations. An iterative process, with the weighted parameters flow resistance (1), shear stress (2) and velocity (3), was necessary to determine the best rotated orientation. Blood flow was optimal at a 45° rotation from the standard implantation orientation, which will offer a supply to the coronary arteries.
No takes yet. Share an insight, caveat, or question.
Bongert et al. (2018) studied Heart valve disease requiring aortic valve replacement. Rotational mounting positions of aortic prosthetic valves (45° rotation) vs. Standard implantation orientation was evaluated on Optimal blood flow (flow resistance, shear stress, and velocity). A 45° rotation of the prosthetic aortic valve from the standard implantation orientation optimized blood flow parameters including flow resistance, shear stress, and velocity in a computational model.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: