Key result
Low-sodium haemodialysis significantly reduced mean 48-h inter-dialytic blood pressure from 141/83 mmHg to 133/78 mmHg compared to usual sodium dialysate (P<0.01).
Why the study?
Does low-sodium haemodialysis without fluid removal improve blood pressure control in chronic haemodialysis patients?
Population
10 chronic stable haemodialysis patients, mean age 67 years, 8 men and 2 women.
Comparison
Low-sodium haemodialysis without extra fluid… vs Usual sodium dialysate for 2 weeks.
Design
Cohort
Follow-up
4 weeks (two 2-week periods)
Authors
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May support low-sodium dialysate for inter-dialytic BP control in HD; leaves open need for RCTs on CV outcomes.
Does low-sodium haemodialysis without fluid removal improve blood pressure control in chronic haemodialysis patients?
Absolute Event Rate: 133% vs 141%
p-value: p=<0.01
Modest reduction in dialysate sodium without extra fluid removal significantly improves inter-dialytic blood pressure and reduces systemic vascular resistance in chronic haemodialysis patients.
Farmer et al. (2000) studied chronic haemodialysis (n=10). Low-sodium dialysate vs. Usual sodium dialysate (138-140 mmol/L) was evaluated on Mean 48 h inter-dialytic systolic blood pressure (p=<0.01). Low-sodium haemodialysis significantly reduced mean 48-h inter-dialytic blood pressure from 141/83 mmHg to 133/78 mmHg compared to usual sodium dialysate (P<0.01).
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