Key result
The reactive lysyl residue of myosin subfragment 1 exhibited an anomalously low pK value of 9.0 and a high maximal rate of trinitrophenylation, likely caused by a vicinal positive charge.
Population
Myosin subfragment 1
Design
Preclinical
Authors
Loading...
Provides foundational myosin kinetics insight; leaves open translation to human cardiac function.
The study characterizes the anomalous ionization behavior of the reactive lysyl residue in myosin subfragment 1, suggesting influence by a vicinal positive charge.
Mühlrád et al. (1981) studied this question. 2,4,6-trinitrobenzenesulfonate was evaluated on Rate of trinitrophenylation and pH dependence. The reactive lysyl residue of myosin subfragment 1 exhibited an anomalously low pK value of 9.0 and a high maximal rate of trinitrophenylation, likely caused by a vicinal positive charge.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: