Population
Myosin subfragment 1 (myosin-S1)
Comparison
Reductive methylation (RM-S1) vs Unmodified myosin-S1 (control S1)
Design
Preclinical
Authors
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Reductive methylation slows actin-activated myosin ATPase in vitro; leaves open effects on cardiac contractility in vivo.
Reductive methylation of myosin-S1 alters its kinetic mechanism, decreasing the maximum steady-state rate of ATP hydrolysis at saturating actin while increasing it in the absence of actin.
White et al. (1993) studied this question.
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