September 1, 1994Biochemistry

Extensively Methylated Myosin Subfragment-1: Examination of Local Structure, Interactions with Nucleotides and Actin, and Ligand-Induced Conformational Changes

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Population

Myosin subfragment-1 (S1)

Comparison

Extensive methylation vs Unmethylated S1 (implied)

Design

Preclinical

Authors

BPBrigitte C. PhanUniversity of Arizona PCPearl CheungUniversity of South Australia MJMeliana Christianti J.University of Minho

Discussion

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Implication

Methylation-induced myosin defects warrant no clinical change; hypothesis-generating for post-translational effects in cardiac models.

Structured PICO

Population

Myosin subfragment-1 (S1)

Intervention

Extensive methylation

Comparator

Unmethylated S1 (implied)

Outcome

Effect on S1 structure and function (affinity for actin, nucleotide dissociation, in vitro motility)surrogate

Extensive methylation of myosin subfragment-1 causes numerous structural and functional impairments, including loss of in vitro motility and impaired communication between binding sites.

Cite This Study

Phan et al. (1994) studied this question.

synapsesocial.com/papers/6a71430175498292b70abdee https://doi.org/10.1021/bi00203a026

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Extensively Methylated Myosin Subfragment-1: Examination of Local Structure, Interactions with Nucleotides and Actin, and Ligand-Induced Conformational Changes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Extensively Methylated Myosin Subfragment-1: Examination of Local Structure, Interactions with Nucleotides and Actin, and Ligand-Induced Conformational Changes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider