Population
In vitro biochemical model using myosin subfragment 1 isoenzymes and actin
Comparison
Varying ionic strength and actin concentrations vs Comparison between S-1 and S-1 isoenzymes
Design
Preclinical
Authors
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No immediate clinical implications; leaves open ionic modulation of cardiac myosin kinetics in vivo.
The study demonstrates that the kinetic differences between myosin S-1 isoenzymes A1 and A2 are modulated by ionic strength, which alters the rate-limiting step of ATP hydrolysis for S-1 (A1).
Wagner et al. (1979) studied this question.
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