Key result
Arachidonic acid-mediated activation of BK channels is impaired in Zucker Diabetic Fatty rats (98% enhancement) compared to lean controls (274% enhancement) due to reduced PGI2 synthase activity.
Population
Coronary arterial smooth myocytes and small coronary arteries from lean control and Zucker Diabetic Fatty rats
Comparison
Arachidonic acid 1 micromol/l and iloprost vs Lean control rats
Design
Preclinical
Authors
Loading...
Impaired coronary vasorelaxation in diabetic rats leaves open whether PGI2 synthase restoration could improve human outcomes; human studies required.
Absolute Event Rate: 98% vs 274%
Arachidonic acid-mediated BK channel activation and vasorelaxation are impaired in the coronary arteries of diabetic rats due to reduced prostacyclin synthase activity.
Lü et al. (2005) studied Diabetes/Obesity (Zucker Diabetic Fatty Rats). Zucker Diabetic Fatty (ZDF) phenotype vs. Lean control rats was evaluated on BK current enhancement by 1 micromol/l arachidonic acid. Arachidonic acid-mediated activation of BK channels is impaired in Zucker Diabetic Fatty rats (98% enhancement) compared to lean controls (274% enhancement) due to reduced PGI2 synthase activity.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: