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February 6, 2003Circulation ResearchOpen Access

Diabetes Mellitus Impairs Vasodilation to Hypoxia in Human Coronary Arterioles

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Why the study?

Does diabetes mellitus impair vasodilation to hypoxia and K(ATP) opening in human coronary arterioles?

Population

Human coronary arterioles dissected from right atrial appendage of patients with type 1 or type 2 diabetes…

Comparison

Exposure to hypoxia and aprikalim (a selective K… vs Arterioles from patients without diabetes mellitus

Design

Preclinical

Authors

HMHiroto MiuraTokyo University of Agriculture and TechnologyRWRuth E. WachtelUniversity of IowaFLFausto R. LoberizaSanofi (France)

Discussion

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Implication

May increase ischemic risk in DM; animal data leave open whether K(ATP) modulation alters human outcomes.

Structured PICO

Does diabetes mellitus impair vasodilation to hypoxia and K(ATP) opening in human coronary arterioles?

P
Population
Human coronary arterioles dissected from right atrial appendage of patients with type 1 or type 2 diabetes mellitus (DM) and patients without DM.
I
Intervention
Exposure to hypoxia and aprikalim (a selective K(ATP) opener)
C
Comparator
Arterioles from patients without diabetes mellitus
O
Outcome
Vasodilation (maximum dilation) to hypoxia and aprikalimsurrogate

Diabetes mellitus impairs human coronary arteriolar dilation to K(ATP) opening, leading to reduced dilation to hypoxia, which may contribute to greater cardiovascular morbidity in diabetic patients.

Cite This Study

Miura et al. (2003) studied this question.

synapsesocial.com/papers/6a73820f30bc69be694e6306https://doi.org/10.1161/01.res.0000052671.53256.49
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impaired microvascular response to graded coronary occlusion in diabetic and hyperglycemic dogs1995 · 64 citations
  2. 2Impairment of Coronary Vascular Reserve and ACh-Induced Coronary Vasodilation in Diabetic Patients With Angiographically Normal Coronary Arteries and Normal Left Ventricular Systolic Function1993 · 455 citations
  3. 3Hypoxic Dilation of Coronary Arteries Is Mediated by ATP-Sensitive Potassium Channels1990 · 599 citations
  4. 4ATP-sensitive potassium channel is essential to maintain basal coronary vascular tone in vivo1992 · 167 citations
  5. 5Effects of Hypoxia on Isometric Force, Intracellular Ca2+, pH, and Energetics in Porcine Coronary Artery2000 · 63 citations