Key result
Homogeneously prolonging action potential duration by delaying ventricular repolarization serves as an effective anti-arrhythmic principle, as demonstrated by agents like amiodarone and sotalol.
Design
Review
Authors
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May guide class III agent selection in arrhythmias; extends mechanistic evidence but leaves open modern RCT confirmation.
The paper outlines the theoretical framework that homogeneously delaying ventricular repolarization (prolonging action potential duration) serves as an effective anti-arrhythmic principle.
E. M. Vaughan Williams (1985) conducted a review in Arrhythmia. Delayed ventricular repolarization agents (e.g., amiodarone, sotalol) was evaluated. Homogeneously prolonging action potential duration by delaying ventricular repolarization serves as an effective anti-arrhythmic principle, as demonstrated by agents like amiodarone and sotalol.
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