Why the study?
Does the severity of proteinuria correlate with the rate of renal decline in adults?
Population
638,150 adults from a province-wide registry in Alberta, Canada, who had a measure of proteinuria and three…
Comparison
Proteinuria of varying severity (mild and heavy) vs Normal proteinuria
Design
Cohort
Follow-up
≥1 year
Key result
Proteinuria of increasing severity was associated with a faster rate of renal decline regardless of baseline eGFR, with heavy proteinuria in men with baseline eGFR 45-59.9 correlating with an eGFR decline of 2.16 ml/min/1.73m2 per year.
Authors
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May refine CKD prognosis beyond eGFR; extends observational data but leaves causal effects and interventions open.
Cohort (n=638,150)
Does the severity of proteinuria correlate with the rate of renal decline in adults?
Effect estimate: Change in eGFR of -2.16 ml/min per 1.73 m2 per year (95% CI -2.37 to -1.95)
Proteinuria of increasing severity is associated with a faster rate of renal decline regardless of baseline eGFR, emphasizing the need to assess both parameters in patients with CKD.
Turin et al. (2013) conducted a cohort in Chronic kidney disease (n=638,150). Proteinuria vs. Normal protein levels was evaluated on Rate of change in estimated GFR (eGFR) per year (Change in eGFR of -2.16 ml/min per 1.73 m2 per year, 95% CI -2.37 to -1.95). Proteinuria of increasing severity was associated with a faster rate of renal decline regardless of baseline eGFR, with heavy proteinuria in men with baseline eGFR 45-59.9 correlating with an eGFR decline of 2.16 ml/min/1.73m2 per year.
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