Why the study?
Does the magnitude of early proteinuria reduction predict the long-term progression of hypertensive kidney disease?
Population
1094 African Americans with hypertensive renal disease (GFR, 20-65 mL/min per 1.73 m2)
Design
Cohort, randomized 3 x 2 factorial trial (original trial design)
Follow-up
median 3.8 years
Authors
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Early proteinuria changes may predict GFR decline in hypertensive kidney disease; leaves open whether reduction alters progression.
Does the magnitude of early proteinuria reduction predict the long-term progression of hypertensive kidney disease?
Early changes in proteinuria predict the subsequent progression of hypertensive kidney disease, suggesting proteinuria reduction is a valuable prognostic marker.
Janice P. Lea (2005) studied this question.
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