November 15, 1995Annals of Internal Medicine

The low blood pressure goal had a greater beneficial effect on GFR decline in persons with higher baseline proteinuria in both study A (P = 0.02) and study B (P = 0.01).

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Why the study?

Does a low blood pressure goal reduce the rate of decline in glomerular filtration rate and proteinuria in patients with chronic renal disease?

Population

840 patients with chronic renal diseases of diverse cause. Excluded diabetic patients requiring insulin.

Comparison

Low blood pressure goal vs Usual blood pressure goal

Design

RCT, randomly assigned

Authors

JPJohn C. PetersonMoffitt Cancer Center

Discussion

Member takes

Overview

Supports lower BP goals preferentially in proteinuric CKD; extends RCT evidence for proteinuria as modifier of GFR benefit.

Structured PICO

Does a low blood pressure goal reduce the rate of decline in glomerular filtration rate and proteinuria in patients with chronic renal disease?

Population

840 patients with chronic renal diseases of diverse cause (585 in study A with GFR 25-55 ml/min/1.73m2, 255 in study B with GFR 13-24 ml/min/1.73m2). Excluded diabetic patients requiring insulin.

Intervention

Low blood pressure goal (target mean arterial pressure ≤ 92 mm Hg for patients ≤ 60 years of age and ≤ 98 mm Hg for patients ≥ 61 years of age)

Comparator

Usual blood pressure goal (target mean arterial pressure ≤ 107 mm Hg for patients ≤ 60 years of age and ≤ 113 mm Hg for patients ≥ 61 years of age)

Outcome

Rate of decline in glomerular filtration rate and change in proteinuria during follow-upsurrogate

A lower blood pressure goal slows the progression of renal disease more effectively in patients with higher baseline proteinuria.

Cite This Study

John C. Peterson (1995) studied this question.

synapsesocial.com/papers/6a7cdebee54b2084843e15f2 https://doi.org/10.7326/0003-4819-123-10-199511150-00003

View Full Paper

Ask AI

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November 15, 1995Annals of Internal Medicine

The low blood pressure goal had a greater beneficial effect on GFR decline in persons with higher baseline proteinuria in both study A (P = 0.02) and study B (P = 0.01).

View Full Paper

Ask AI

Bookmark

Why the study?

Does a low blood pressure goal reduce the rate of decline in glomerular filtration rate and proteinuria in patients with chronic renal disease?

Population

840 patients with chronic renal diseases of diverse cause. Excluded diabetic patients requiring insulin.

Comparison

Low blood pressure goal vs Usual blood pressure goal

Design

RCT, randomly assigned

Authors

JPJohn C. PetersonMoffitt Cancer Center

Discussion

Member takes

Overview

Supports lower BP goals preferentially in proteinuric CKD; extends RCT evidence for proteinuria as modifier of GFR benefit.

Structured PICO

Does a low blood pressure goal reduce the rate of decline in glomerular filtration rate and proteinuria in patients with chronic renal disease?

Population

840 patients with chronic renal diseases of diverse cause (585 in study A with GFR 25-55 ml/min/1.73m2, 255 in study B with GFR 13-24 ml/min/1.73m2). Excluded diabetic patients requiring insulin.

Intervention

Low blood pressure goal (target mean arterial pressure ≤ 92 mm Hg for patients ≤ 60 years of age and ≤ 98 mm Hg for patients ≥ 61 years of age)

Comparator

Usual blood pressure goal (target mean arterial pressure ≤ 107 mm Hg for patients ≤ 60 years of age and ≤ 113 mm Hg for patients ≥ 61 years of age)

Outcome

Rate of decline in glomerular filtration rate and change in proteinuria during follow-upsurrogate

A lower blood pressure goal slows the progression of renal disease more effectively in patients with higher baseline proteinuria.

Cite This Study

John C. Peterson (1995) studied this question.

synapsesocial.com/papers/6a7cdebee54b2084843e15f2 https://doi.org/10.7326/0003-4819-123-10-199511150-00003

View Full Paper

Ask AI

Bookmark