Why the study?
Does a low blood pressure goal (MAP <= 92 mm Hg) safely achieve lower blood pressure compared to a usual goal (MAP <= 107 mm Hg) in patients with chronic renal disease?
Population
585 patients with chronic renal disease and baseline glomerular filtration rate between 13 and 55 mL/min per…
Comparison
Low blood pressure goal using antihypertensive… vs Usual blood pressure goal.
Design
RCT, randomly assigned
Key result
A low blood pressure goal was achievable in patients with chronic renal disease (achieved MAP 93.0 vs 97.7 mm Hg for usual goal) without serious adverse effects.
Authors
Loading...
Supports lower MAP targets in CKD without serious harm; extends renal protection evidence to proteinuric patients.
RCT (n=585)
Does a low blood pressure goal (MAP <= 92 mm Hg) safely achieve lower blood pressure compared to a usual goal (MAP <= 107 mm Hg) in patients with chronic renal disease?
Absolute Event Rate: 93% vs 97.7%
A lower blood pressure goal (MAP <= 92 mm Hg) is achievable and safe in patients with chronic renal disease without cardiovascular disease, though it requires more medication changes and causes more symptoms of low blood pressure.
Lazarus et al. (1997) conducted an RCT in Chronic Renal Disease (n=585). Low blood pressure goal (mean arterial pressure ≤ 92 mm Hg) vs. Usual blood pressure goal (mean arterial pressure ≤ 107 mm Hg) was evaluated on Achieved mean arterial pressure. A low blood pressure goal was achievable in patients with chronic renal disease (achieved MAP 93.0 vs 97.7 mm Hg for usual goal) without serious adverse effects.