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May 12, 2026Scientific ReportsOpen Access

Changes in urine dipstick proteinuria and risk of dialysis-requiring acute kidney injury and subsequent ESRD

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Authors

SPSung Keun ParkMKMin-Ho KimCOChang‐Mo Oh

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Overview

Randomized trial finds changes in proteinuria predict risk of dialysis-requiring AKI and ESRD in Koreans, suggesting a need for monitoring.

Key Points

  • This research investigates the relationship between changes in urine protein levels and the risk of severe acute kidney injury (AKI) leading to end-stage renal disease (ESRD).
  • Included 2,021,548 Koreans who underwent health check-ups in 2005-2006 and 2009.
  • Categorized changes in proteinuria into four groups based on urine dipstick test results.
  • Assessed adjusted hazard ratios and 95% confidence intervals for dialysis-requiring AKI and subsequent ESRD over a median follow-up of 11.84 years.
  • The risk for dialysis-requiring AKI was highest in persistent proteinuria (HR 3.643 [2.881-4.607]), followed by incident (HR 1.922 [1.694-2.181]) and resolved proteinuria (HR 1.453 [1.194-1.767]).
  • The risk for ESRD also increased with persistent proteinuria (HR 22.883 [15.067-34.755]), incident (HR 7.508 [5.548-10.163]), and resolved (HR 4.813 [2.970-7.800]) compared to negative proteinuria.
  • All patterns of change in proteinuria were significantly linked to an increased risk of dialysis-requiring AKI and ESRD.

Cite This Study

Park et al. (2026) studied this question.

synapsesocial.com/papers/6a02c2b9ce8c8c81e96403dehttps://doi.org/10.1038/s41598-026-52243-x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Proteinuria and Rate of Change in Kidney Function in a Community-Based Population2013 · 122 citations
  2. 2#1052 Associations of new-onset proteinuria during hospitalization with all-cause mortality and kidney outcome2024
  3. 3Direct, Progressive Association of Cardiovascular Risk Factors With Incident Proteinuria2005 · 59 citations
  4. 4Associations among Estimated Glomerular Filtration Rate, Proteinuria, and Adverse Cardiovascular Outcomes2011 · 154 citations
  5. 5The association between changes in proteinuria and the risk of cerebral infarction in the Korean population2022 · 5 citations