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September 17, 2022Diabetes Research and Clinical PracticeOpen Access

The association between changes in proteinuria and the risk of cerebral infarction in the Korean population

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Why the study?

Proteinuria is a known risk factor for cerebral infarction that can change over time, but data on the association between changes in proteinuria and cerebral infarction risk were scarce.

Does a change in proteinuria status affect the risk of cerebral infarction in a Korean population?

Population

276,861 Koreans assessed for urine dipstick proteinuria in 2003-2004 and 2007-2008

Comparison

Resolved, incident, and persistent proteinuria vs negative proteinuria

Design

Cohort study

Follow-up

Until 2013

Authors

SPSung Keun ParkJJJu Young JungMKMin Ho Kim

Discussion

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Member takes

Overview

Proteinuria trajectory may refine cerebral infarction risk assessment; leaves open whether modifying proteinuria alters incidence in trials.

Structured PICO

Does a change in proteinuria status affect the risk of cerebral infarction in a Korean population?

P
Population
276,861 Koreans assessed for urine dipstick proteinuria both in 2003-2004 and 2007-2008
I
Intervention
Changes in proteinuria over 4 years (resolved: proteinuria ≥ 1+ → negative, incident: negative → proteinuria ≥ 1+, persistent: proteinuria ≥ 1+ → proteinuria ≥ 1+)
C
Comparator
Negative proteinuria (negative → negative)
O
Outcome
Cerebral infarction until 2013hard clinical

Any history of proteinuria, even if resolved, is associated with an increased risk of cerebral infarction compared to persistently negative proteinuria.

Cite This Study

Park et al. (2022) studied this question.

synapsesocial.com/papers/6a892b0b3fe85f489c1ff9bchttps://doi.org/10.1016/j.diabres.2022.110090
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Changes in proteinuria and the associated risks of ischemic heart disease, acute myocardial infarction,and angina pectoris in Korean population2023 · 2 citations
  2. 2Direct, Progressive Association of Cardiovascular Risk Factors With Incident Proteinuria2005 · 59 citations
  3. 3Association between Proteinuria Status and Risk of Hypertension: A Nationwide Population-Based Cohort Study2023 · 11 citations
  4. 4Changes in urine dipstick proteinuria and risk of dialysis-requiring acute kidney injury and subsequent ESRD2026
  5. 5Persistent proteinuria is associated with the occurrence of cardiovascular disease: a nationwide population-based cohort study2024 · 4 citations