Why the study?
Proteinuria is an important risk factor for CVD, but the association between changes in proteinuria and the occurrence of CVD needed to be determined.
Does the change in proteinuria status (improvement, progression, or persistence) affect the risk of composite cardiovascular disease in the general population?
Population
1,708,712 participants who consecutively underwent national health examinations
Comparison
Proteinuria-improved vs proteinuria-progressed vs proteinuria-persistent vs normal
Design
Nationwide population-based cohort study
Follow-up
Median of 14.2 years
Key result
Persistent proteinuria significantly increased the risk of composite cardiovascular disease compared to normal proteinuria status (HR 1.78).
Authors
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Improvement in proteinuria status was associated with lower CVD risk than persistence or progression; hypothesis-generating and requires prospective validation.
Cohort (n=1,708,712)
Does the change in proteinuria status (improvement, progression, or persistence) affect the risk of composite cardiovascular disease in the general population?
Effect estimate: HR 1.78 (95% CI 1.64-1.94)
p-value: p=<0.001
Persistent proteinuria is associated with an increased risk of cardiovascular disease, while improvement in proteinuria status lowers this risk compared to persistent or progressed states.
Woo et al. (2024) conducted a cohort in Cardiovascular disease (n=1,708,712). Persistent proteinuria vs. Normal proteinuria was evaluated on Composite cardiovascular disease (all-cause death, all strokes, and myocardial infarction) (HR 1.78, 95% CI 1.64-1.94, p=<0.001). Persistent proteinuria significantly increased the risk of composite cardiovascular disease compared to normal proteinuria status (HR 1.78).