Key result
Trace and positive proteinuria linked to up to ~59% higher incident heart failure risk.
Why the study?
Heart failure prevalence is increasing globally, and it was unclear whether adults with trace and positive proteinuria have a higher risk for incident HF compared to those with negative proteinuria.
Does trace or positive proteinuria increase the risk of incident heart failure in adults without known cardiovascular disease?
Observational (n=1,021,943)
Yes
Does trace or positive proteinuria increase the risk of incident heart failure in adults without known cardiovascular disease?
Effect estimate: HR 1.09 (trace) and HR 1.59 (positive) (95% CI 1.03-1.15 (trace) and 1.49-1.70 (positive))
Even trace proteinuria on a standard urine dipstick is associated with a significantly increased risk of incident heart failure in a general population without prior cardiovascular disease.
No takes yet. Share an insight, caveat, or question.
Trace proteinuria may aid HF risk stratification in primary prevention; hypothesis-generating and requires prospective validation before practice change.
Fukui et al. (2021) conducted an observational in Heart failure (n=1,021,943). Trace and positive proteinuria vs. Negative proteinuria was evaluated on Incident heart failure (HR 1.09 (trace) and HR 1.59 (positive), 95% CI 1.03-1.15 (trace) and 1.49-1.70 (positive)). Trace and positive proteinuria were associated with a higher risk of incident heart failure compared to negative proteinuria (HR 1.09, 95% CI 1.03-1.15 and HR 1.59, 95% CI 1.49-1.70, respectively).
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