Key result
Repetitive proteinuria linked to ~108% higher risk of major cardiovascular events versus no proteinuria.
Why the study?
The authors aimed to investigate the association between repetitive proteinuria and cardiovascular events among the middle-aged and older general Japanese population.
Does repetitive proteinuria increase the risk of major cardiovascular events in middle-aged and older adults?
Cohort (n=88,744)
Does repetitive proteinuria increase the risk of major cardiovascular events in middle-aged and older adults?
Effect estimate: HR 2.08 (95% CI 1.67-2.59)
Repeatedly detected proteinuria during annual screening is a significant risk factor for major cardiovascular events in the general population.
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Repetitive proteinuria may refine CV risk assessment during routine screening; leaves open whether interventions targeting it improve outcomes.
Ohnishi et al. (2023) conducted a cohort in General population (n=88,744). Repetitively-positive proteinuria vs. All-negative proteinuria was evaluated on Hospitalisation or death due to acute myocardial infarction (AMI), cerebrovascular diseases, heart failure (HF) or peripheral vascular diseases (PVDs) (HR 2.08, 95% CI 1.67-2.59). Repetitive proteinuria across annual kidney function screenings was associated with a higher risk of major cardiovascular events compared to no proteinuria (HR 2.08; 95% CI 1.67-2.59).
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