Why the study?
Proteinuria is associated with cardiovascular disease, but the relationship between changes in proteinuria status and hypertension remains unclear.
Is change in proteinuria status associated with the risk of developing hypertension in individuals without prior hypertension?
Population
935,723 participants without prior hypertension history from the Korean National Health Insurance Database
Comparison
Proteinuria-resolved vs proteinuria-developed vs chronic proteinuria vs proteinuria-free groups
Design
Nationwide population-based cohort study
Follow-up
Median of 14.2 years
Key result
Recovering from proteinuria was associated with a significantly lower risk of developing hypertension compared to having chronic proteinuria (HR 0.58; 95% CI 0.53-0.63; p<0.001).
Authors
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Proteinuria resolution may lower hypertension risk; hypothesis-generating and requires interventional trials before practice change.
Cohort (n=935,723)
Is change in proteinuria status associated with the risk of developing hypertension in individuals without prior hypertension?
Effect estimate: HR 0.58 (95% CI 0.53-0.63)
p-value: p=<0.001
Changes in proteinuria status are significantly associated with the risk of developing hypertension, suggesting that resolving proteinuria may decrease hypertension risk.
Lee et al. (2023) conducted a cohort in Proteinuria (n=935,723). Recovery from proteinuria vs. Chronic proteinuria was evaluated on Incidence of hypertension (HR 0.58, 95% CI 0.53-0.63, p=<0.001). Recovering from proteinuria was associated with a significantly lower risk of developing hypertension compared to having chronic proteinuria (HR 0.58; 95% CI 0.53-0.63; p<0.001).