Key result
Artemisinin significantly protected against doxorubicin-induced nephrotoxicity and testotoxicity in rats by decreasing the overexpression of caspase-3, TNF-α, iNOS, and NF-κB.
Why the study?
Artemisinin possesses protective effects against several tissue injuries, but its effects on doxorubicin-induced renal and testicular toxicity required investigation.
Does artemisinin prevent doxorubicin-induced renal and testicular toxicity in rats?
Does artemisinin prevent doxorubicin-induced renal and testicular toxicity in rats?
Artemisinin demonstrates protective effects against doxorubicin-induced nephrotoxicity and testicular toxicity in a rat model by reducing inflammatory and apoptotic markers.
May support preclinical investigation of artemisinin for doxorubicin toxicity; leaves open any clinical translation.
Artemisinin, an antimalarial drug, has anticancer activity and possesses protective effects against several tissue injuries. The aim of the present study was to investigate the effects of artemisinin on doxorubicin-induced renal and testicular toxicity in rats. Doxorubicin was administered to rats at a single dose of 10 mg/kg body weight (b.w.) as a single intraperitoneal injection. Application of artemisinin was by using oral gavage feeding needle for 14 days at different specified doses (7 mg/kg and 35 mg/kg b.w.). At the end of the experiments, kidney and testis samples were collected and used for histopathological and immunohistochemical examinations. At histopathological examination, while hyperemia was the marked finding in kidney and testis of rats treated with doxorubicin only, no evidence of structural abnormalities showed in other groups. Immunohistochemical examination of the testes and kidneys demonstrated significantly increased expression of caspase-3, TNF-α, iNOS and NF-κB in rats treated with doxorubicin only. Artemisinin decreased the doxorubicin-induced overexpression of NF-κB, iNOS, TNFα and caspase-3 in these tissues of rats. Artemisinin can protect the kidney and testis against doxorubicin-induced nephrotoxicity and testotoxicity, probably through a decrease of caspase-3, TNF-α, iNOS and NF-κB expressions. It may be concluded that artemisinin has a potential for clinical use in the treatment of kidney and testis damage induced by doxorubicin. Further researches are required to determine the appropriate combination of artemisinin with doxorubicin.
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Tutun et al. (2019) studied Doxorubicin-induced renal and testicular toxicity (n=49). Artemisinin vs. Doxorubicin only was evaluated on Expression of caspase-3, TNF-α, iNOS, and NF-κB in kidney and testis tissues (p=<0.001). Artemisinin significantly protected against doxorubicin-induced nephrotoxicity and testotoxicity in rats by decreasing the overexpression of caspase-3, TNF-α, iNOS, and NF-κB.
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