Key result
Artemisia annua leaf extract mitigated doxorubicin-induced hepatotoxicity in rats by restoring biochemical parameters and antioxidant gene expression via PI-3K/Akt/Nrf-2 signaling activation.
Why the study?
Doxorubicin has harmful effects that limit its therapeutic application, making preventive agents against doxorubicin-induced injury imperative.
Does Artemisia annua leaf extract attenuate doxorubicin-induced hepatic injury in rats?
Comparison
DOX plus AALE vs DOX alone vs AALE alone vs negative control
Design
Animal experimental study
Follow-up
A month
Authors
Loading...
Should not yet inform clinical DOX use; leaves open translational potential of AALE in chemotherapy toxicity models.
Does Artemisia annua leaf extract attenuate doxorubicin-induced hepatic injury in rats?
Artemisia annua leaf extract attenuates doxorubicin-induced hepatic injury in rats through activation of the PI-3K/Akt/Nrf-2 signaling pathway.
El-Said et al. (2023) studied Doxorubicin-induced hepatic toxicity (n=40). Artemisia annua leaf extract (AALE) vs. Doxorubicin alone (4 mg/kg i.p once a week) was evaluated on Hepatic toxicity (body weight changes, biochemical, molecular, and histopathological investigations). Artemisia annua leaf extract mitigated doxorubicin-induced hepatotoxicity in rats by restoring biochemical parameters and antioxidant gene expression via PI-3K/Akt/Nrf-2 signaling activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: