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September 6, 2019Biotechnic & Histochemistry

Artemisinin attenuates doxorubicin induced cardiotoxicity and hepatotoxicity in rats

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Why the study?

The study investigated the effects of artemisinin on doxorubicin-induced heart and liver pathology in rats.

Does artemisinin reduce doxorubicin-induced cardiotoxicity and hepatotoxicity in rats?

Population

49 male rats

Comparison

Artemisinin (7 mg/kg or 35 mg/kg) vs doxorubicin alone vs untreated control vs 0.9% NaCl

Design

Preclinical animal study

Follow-up

14 days

Authors

İAİbrahim AktaşAdıyaman UniversityÖÖÖzlem ÖzmenUniversity of Health ScienceHTHidayet TutunBurdur Mehmet Akif Ersoy Üniversitesi

Discussion

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Overview

Artemisinin attenuated doxorubicin toxicity markers in rats; hypothesis-generating and leaves open clinical translation.

Structured PICO

Does artemisinin reduce doxorubicin-induced cardiotoxicity and hepatotoxicity in rats?

P
Population
49 male rats
I
Intervention
Artemisinin administered by gavage at a dose of 7 mg/kg or 35 mg/kg for 14 days following doxorubicin administration
C
Comparator
Doxorubicin alone, untreated control, or 0.9% NaCl
O
Outcome
Histopathology and immunohistochemical expression of caspase-3, TNF-α, iNOS and NF-κB in heart and liver samples at 14 dayssurrogate

Artemisinin may offer protective effects against doxorubicin-induced cardiotoxicity and hepatotoxicity by reducing inflammation and apoptosis in a rat model.

Cite This Study

Aktaş et al. (2019) studied this question.

synapsesocial.com/papers/6a8564300ef7f4b747b54dfdhttps://doi.org/10.1080/10520295.2019.1647457
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Also Consider

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