Key result
Small molecule tyrosine kinase inhibitors are associated with cardiovascular side effects including hypertension, heart failure, and QTc prolongation, which may benefit from systems-based approaches.
Population
Patients receiving small molecule tyrosine kinase inhibitors (TKIs) for malignancies
Design
Review
Authors
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May guide TKI cardiotoxicity monitoring; leaves open prospective validation of systems medicine approaches.
This review highlights the mechanisms of TKI-induced cardiovascular toxicities and advocates for systems-based approaches to manage cardiovascular wellness in cancer survivors.
Nhola et al. (2016) conducted a review in Cancer and cardiovascular toxicity. Small molecule tyrosine kinase inhibitors (TKIs) was evaluated. Small molecule tyrosine kinase inhibitors are associated with cardiovascular side effects including hypertension, heart failure, and QTc prolongation, which may benefit from systems-based approaches.
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