Key result
Neonatal inoculation of rhesus monkeys with Mason-Pfizer monkey virus frequently induced pneumonia, enteritis, lymphadenopathy, thymic atrophy, and a disease suggestive of an autoimmune response.
Why the study?
Does neonatal inoculation with Mason-Pfizer monkey virus induce disease in infant rhesus monkeys?
Population
Infant rhesus monkeys
Design
Preclinical
Authors
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May model retroviral autoimmunity in neonates; leaves open human relevance.
Does neonatal inoculation with Mason-Pfizer monkey virus induce disease in infant rhesus monkeys?
Neonatal inoculation of rhesus monkeys with M-PMV induces a disease characterized by pneumonia, enteritis, and lymphoid changes suggestive of a slow-virus-induced autoimmune response.
Fine et al. (1975) studied Mason-Pfizer monkey virus (M-PMV) infection. Inoculation with Mason-Pfizer monkey virus (M-PMV) and virus-infected cells was evaluated on Development of viral and/or bacterial pneumonia and enteritis. Neonatal inoculation of rhesus monkeys with Mason-Pfizer monkey virus frequently induced pneumonia, enteritis, lymphadenopathy, thymic atrophy, and a disease suggestive of an autoimmune response.
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