Key result
Inoculation of Macacus rhesus monkeys with an attenuated strain of poliomyelitis virus resulted in a benign disease ending in recovery rather than death, conferring a protective effect.
Why the study?
Does inoculation with an attenuated strain of poliomyelitis virus provide protective effect and result in recovery in Macacus rhesus monkeys?
Population
Macacus rhesus monkeys
Comparison
Inoculation with an attenuated strain of the… vs Previously described examples of experimental…
Design
Preclinical
Authors
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Provides proof-of-concept for attenuated-virus immunization in primates; leaves open translation to human poliomyelitis prevention.
Does inoculation with an attenuated strain of poliomyelitis virus provide protective effect and result in recovery in Macacus rhesus monkeys?
An attenuated strain of poliomyelitis virus induces a benign, immunizing infection in monkeys that ends in recovery rather than death.
Flexner et al. (1924) studied Poliomyelitis. Attenuated strain of poliomyelitis virus vs. Previously described examples of experimental poliomyelitis was evaluated on Infective power and protective effect (survival/recovery). Inoculation of Macacus rhesus monkeys with an attenuated strain of poliomyelitis virus resulted in a benign disease ending in recovery rather than death, conferring a protective effect.
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